135266-95-4

Basic information

• Product Name: 4-Nitrophenyl 2-(AcetylaMino)-2-deoxy-α-D-galactopyranoside 3,4,6-Triacetate
• Synonyms: 4-Nitrophenyl 2-(AcetylaMino)-2-deoxy-α-D-galactopyranoside 3,4,6-Triacetate
• CAS NO: 135266-95-4
• Molecular Formula: C₂₀H₂₄N₂O₁₁
• Molecular Weight: 468.41136
• Product Categories: Oligosaccharides
• Mol File: 135266-95-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 654.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• Solubility: Dichloromethane, Methanol
• PKA: 13.22±0.70(Predicted)
• CAS DataBase Reference: 4-Nitrophenyl 2-(AcetylaMino)-2-deoxy-α-D-galactopyranoside 3,4,6-Triacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitrophenyl 2-(AcetylaMino)-2-deoxy-α-D-galactopyranoside 3,4,6-Triacetate(135266-95-4)
• EPA Substance Registry System: 4-Nitrophenyl 2-(AcetylaMino)-2-deoxy-α-D-galactopyranoside 3,4,6-Triacetate(135266-95-4)

Safety Data

• Hazardous Substances Data: 135266-95-4(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Syrup

Uses

4-Nitrophenyl 2-(Acetylamino)-2-deoxy-α-D-galactopyranoside 3,4,6-Triacetate (cas# 135266-95-4) is a compound useful in organic synthesis.

Upstream product

• 100-02-7 4-nitro-phenol 
• 76375-60-5 (3R,4R,5R,6R)-3-acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate 

Relevant articles and documents

Synthesis and Characterization of Versatile O-Glycan Precursors for Cellular O-Glycomics

Protein O-glycosylation is a universal post-translational modification and plays essential roles in many biological processes. Recently we reported a technology termed cellular O-glycome reporter/amplification (CORA) to amplify and profile mucin-type O-glycans of living cells growing in the presence of peracetylated Benzyl-α-GalNAc (Ac3GalNAc-α-Bn). However, the application and development of the CORA method are limited by the properties of the precursor benzyl aglycone, which is relatively inert to further chemical modifications. Here we described a rapid parallel microwave-assisted synthesis of Ac3GalNAc-α-Bn derivatives to identify versatile precursors for cellular O-glycomics. In total, 26 derivatives, including fluorescent and bioorthogonal reactive ones, were successfully synthesized. The precursors were evaluated for their activity as acceptors for T-synthase and for their ability to function as CORA precursors. Several of the precursors possessing useful functional groups were more efficient than Ac3GalNAc-α-Bn as T-synthase acceptors and cellular O-glycome reporters. These precursors will advance the CORA technology for studies of functional O-glycomics.