1352708-02-1

Basic information

• Product Name: N-(4-bromo-3-(trifluoromethyl)phenyl)-2-oxo-2-phenylacetamide
• Synonyms: N-(4-bromo-3-(trifluoromethyl)phenyl)-2-oxo-2-phenylacetamide
• CAS NO: 1352708-02-1
• Molecular Weight: 372.141
• Mol File: 1352708-02-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-bromo-3-(trifluoromethyl)phenyl)-2-oxo-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromo-3-(trifluoromethyl)phenyl)-2-oxo-2-phenylacetamide(1352708-02-1)
• EPA Substance Registry System: N-(4-bromo-3-(trifluoromethyl)phenyl)-2-oxo-2-phenylacetamide(1352708-02-1)

Safety Data

• Hazardous Substances Data: 1352708-02-1(Hazardous Substances Data)

Upstream product

• 1074-12-0 phenylglyoxal hydrate 
• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 122-78-1 phenylacetaldehyde 

Relevant articles and documents

Copper-catalyzed aerobic oxidative cross-dehydrogenative coupling of amine and α-carbonyl aldehyde: A practical and efficient approach to α-ketoamides with wide substrate scope

A copper-catalyzed aerobic oxidative cross-dehydrogenative coupling (CDC) of amine with α-carbonyl aldehyde has been developed. Many types of amines are tolerant in this transformation leading to various α-ketoamides compounds. Wide substrate scope, CDC strategy and using air as oxidant make this transformation highly efficient and practical. Molecular oxygen acts not only as the oxidant, but also as an initiator to trigger this catalytic process. Furthermore, mechanism studies show that carbonyl group of α-carbonyl aldehyde plays a role as the directing group to facilitate this chemical process.