135277-08-6

Basic information

• Product Name: 2-(piperidin-1-ylmethyl)benzonitrile
• Synonyms: 2-(piperidin-1-ylmethyl)benzonitrile
• CAS NO: 135277-08-6
• Molecular Formula: C₁₃H₁₆N₂
• Molecular Weight: 200.27954
• Mol File: 135277-08-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 306.9±17.0 °C(Predicted)
• Appearance: /
• Density: 1.07±0.1 g/cm3(Predicted)
• PKA: 8.35±0.10(Predicted)
• CAS DataBase Reference: 2-(piperidin-1-ylmethyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(piperidin-1-ylmethyl)benzonitrile(135277-08-6)
• EPA Substance Registry System: 2-(piperidin-1-ylmethyl)benzonitrile(135277-08-6)

Safety Data

• Hazardous Substances Data: 135277-08-6(Hazardous Substances Data)

Usage

General Description

2-(piperidin-1-ylmethyl)benzonitrile is a chemical compound with the molecular formula C15H18N2. It is a derivative of benzonitrile, a simple aromatic nitrile. The compound contains a piperidine ring, which is a heterocyclic organic compound with a six-membered ring containing nitrogen atom. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds due to its versatile reactivity. The presence of both a piperidine ring and a nitrile group allows for the compound to participate in a wide range of chemical reactions, making it a valuable building block in organic chemistry.

Upstream product

• 110-89-4 piperidine 
• 18698-99-2 2-(2-cyanophenyl)acetic acid 
• 22115-41-9 2-(bromomethyl)benzonitrile 
• 77532-78-6 2-bromo-6-methylbenzonitrile 

Downstream Products

• 135277-17-7 (Z)-2-Piperidinomethyl-benzamidoxim 
• 32743-18-3 (2-(piperidin-1-ylmethyl)phenyl)methanamine 
• 32743-11-6 2-Piperidinomethyl-benzamid 

Relevant articles and documents

Direct Catalytic Decarboxylative Amination of Aryl Acetic Acids

The decarboxylative coupling of a carboxylic acid with an amine nucleophile provides an alternative to the substitution of traditional organohalide coupling partners. Benzoic and alkynyl acids may be directly aminated by oxidative catalysis. In contrast, methods for intermolecular alkyl carboxylic acid to amine conversion, including amidate rearrangements and photoredox-promoted approaches, require stoichiometric activation of the acid unit to generate isocyanate or radical intermediates. Reported here is a process for the direct chemoselective decarboxylative amination of electron-poor arylacetates by oxidative Cu catalysis. The reaction proceeds at (or near) room temperature, uses native carboxylic acid starting materials, and is compatible with protic, electrophilic, and other potentially complicating functionality. Mechanistic studies support a pathway in which ionic decarboxylation of the acid generates a benzylic nucleophile which is aminated in a Chan–Evans–Lam-type process.

Anellated 2,4-benzodiazepines, I

-