1352784-89-4Relevant articles and documents
A new synthetic approach to efavirenz through enantioselective trifluoromethylation by using the ruppert-prakash reagent
Kawai, Hiroyuki,Kitayama, Takashi,Tokunaga, Etsuko,Shibata, Norio
, p. 5959 - 5961 (2011/12/03)
The organocatalyzed asymmetric synthesis of efavirenz was achieved in five steps from a commercially available substrate through the operationally simple, enantioselective trifluoromethylation of an alkynyl ketone by using the Ruppert-Prakash reagent. The present method provides the first example of the enantioselective synthesis of efavirenz by using a direct trifluoromethylation approach. The organocatalyzed asymmetric synthesis of efavirenz was achieved in five steps from a commercially available substrate through the operationally simple, enantioselective trifluoromethylation of an alkynyl ketone by using the Ruppert-Prakash reagent. The present method provides the first example of the enantioselective synthesis of efavirenz by using a direct trifluoromethylation approach.
