1352802-80-2

Upstream product

• 258886-04-3 (5-bromo-2-methylphenyl)methanol 
• 1352802-81-3 (2-methyl-5-(trimethylsilyl)phenyl)methanol 
• 79669-49-1 5-bromo-2-methylbenzoic acid 

Downstream Products

• 1352803-18-9 4-fluoro-N,N-bis(4-methoxybenzyl)-7-(trimethylsilyl)isoquinolin-3-amine 
• 1352803-19-0 4-chloro-7-(trimethylsilyl)-3-(4-((trimethylsilyl)ethynyl)phenyl)isoquinoline 
• 1352803-20-3 3-(3-bromophenyl)-7-(trimethylsilyl)isoquinolin-4-ol 
• 1352803-21-4 3-(4-methoxyphenyl)-4-(methylthio)-7-(trimethylsilyl)isoquinoline 
• 1352803-22-5 diethyl 1-(3-o-tolyl-7-(trimethylsilyl)isoquinolin-4-yl)hydrazine-1,2-dicarboxylate 
• 1417213-10-5 C₂₅H₂₂FIN₂O₂ 
• 1352802-98-2 2-methyl-5-(trimethylsilyl)benzaldehyde tert-butylimine 

Relevant academic research and scientific papers

METHODS FOR PREPARING ISOQUINOLINES

Provided herein are novel synthetic methods of making isoquinolines comprising coupling a metalated N-(2-methylbenzylidene)amine with a nitrile, followed by cyclization, to provide a substituted isoquinoline compound. This new methodology for preparing is

A versatile synthesis of substituted isoquinolines

Lithiated o-tolualdehyde tert-butylimines were shown to condense with nitriles to form eneamido anion intermediates that were trapped in situ with various electrophiles, thus affording a diverse array of highly substituted isoquinolines, many of which are