1352804-13-7

Upstream product

• 88-05-1 2,4,6-trimethylaniline 
• 1352804-10-4 N₂-mesityl-N₄-(1-Boc-piperidin-4-yl)-1,3,5-triazine-2,4,6-triamine 
• 1352804-07-9 6-chloro-N₂-mesityl-N₄-(1-Boc-piperidin-4-yl)-1,3,5-triazine-2,4-diamine 

Downstream Products

• 1381770-30-4 ethyl 4-((4-(4-amino-6-(mesitylamino)-1,3,5-triazin-2-ylamino)piperidin-1-yl)methyl)benzoate 
• 1381770-31-5 4-((4-(4-amino-6-(mesitylamino)-1,3,5-triazin-2-ylamino)piperidin-1-yl)methyl)benzamide 
• 1381770-29-1 N₂-mesityl-N₄-(1-(pyridin-4-ylmethyl)piperidin-4-yl)-1,3,5-triazine-2,4,6-triamine 
• 1381770-35-9 N₂-mesityl-N₄-(1-(4-nitrobenzyl)piperidin-4-yl)-1,3,5-triazine-2,4,6-triamine 
• 1381770-34-8 N₂-(1-benzylpiperidin-4-yl)-N₄-mesityl-1,3,5-triazine-2,4,6-triamine 
• 1381770-33-7 N₂-mesityl-N₄-(1-(4-(methylsulfonyl)benzyl)piperidin-4-yl)-1,3,5-triazine-2,4,6-triamine 
• 1381770-32-6 4-((4-(4-amino-6-(mesitylamino)-1,3,5-triazin-2-ylamino)piperidin-1-yl)methyl)benzenesulfonamide 
• 1381770-36-0 4-((4-(4-amino-6-(mesitylamino)-1,3,5-triazin-2-ylamino)piperidin-1-yl)methyl)benzonitrile 

Relevant academic research and scientific papers

Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors

A novel series of piperidine-linked amino-triazine derivatives were designed, synthesized and evaluated for in vitro anti-HIV activity as non-nucleoside reverse transcriptase inhibitors on the basis of our previous work. Screening results indicated that most compounds showed excellent activity against wild-type HIV-1 with EC50 values in low nanomolar concentration range (especially compound 6b3, EC50 = 4.61 nM, SI = 5945) and high activity against K103N/Y181C resistant mutant strain of HIV-1 with EC50 values in low micromolar concentration range. In addition, preliminary structure-activity relationship and molecular modeling of these new analogs were detailed in this manuscript.