1352822-01-5

Upstream product

• 603-76-9 1-methylindole 
• 768-60-5 4-methoxyphenylacetylen 

Relevant academic research and scientific papers

Diastereoselective Synthesis of Tetrahydrospiro[carbazole-1,3′-indolines] via an InBr3-Catalyzed Domino Diels-Alder Reaction

A simple InBr3-catalyzed domino reaction of indoles, phenylacetylenes, and various 3-methyleneoxindolines in toluene is described. This reaction not only provided a convenient synthetic protocol for polysubstituted tetrahydrospiro[carbazole-1,3′-indolines] in good yields but also gave completely different diastereoisomers of the tetrahydrospiro[carbazole-1,3′-indolines] to that of the previously reported TfOH-catalyzed one-pot reaction of indoles, acetophenones, and 3-methyleneoxindolines. Additionally, the InBr3-catalyzed reaction of the initially prepared 1,1′-bis(indolyl)phenylethanes with 3-phenacylideneoxindolines also gave the corresponding tetrahydrospiro[carbazole-1,3′-indolines] in good yields and with excellent diastereoselectivity. The reaction mechanism involved the sequential in situ generation of reactive dienophilic 3-alkenylindole, the Diels-Alder reaction, and the Lewis acid controlled diastereoisomerization process.

An efficient one pot conversion of alkynes to bis(indolyl) and bis(pyrrolyl)alkanes in aqueous ethanol

Mercury (II) chloride efficiently catalyzes the reaction between indoles /pyrrole and substituted phenyl acetylenes to furnish bis(indolyl)alkane and bis(pyrrolyl)alkane in good to excellent yields under room temperature and moderate reaction time. The re

Rhenium-catalyzed regiodivergent addition of indoles to terminal alkynes

An efficient rhenium-catalyzed site-switchable addition of indoles to terminal alkynes is described. A variety of bisindolylalkane derivatives are expeditiously synthesized in high yields with excellent regioselectivity. Preliminary mechanistic study shed