1352831-40-3

Upstream product

• 1352831-39-0 2-(4-dimethylamino-1,8-naphthalimido)ethylformamide 
• 81-84-5 1,8-Naphthalic anhydride 
• 77976-79-5 4-(N,N-dimethylamino)-1,8-naphthalic anhydride 
• 81-86-7 4-bromo-1,8-naphthalenedicarboxylic anhydride 

Downstream Products

• 1352831-60-7 tert-butyl 2-((4S,7S,10S,12aS,17R,17aS)-4-benzyl-17-((2-(6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)carbamoyl)-10-isopropyl-3,6,9,12-tetraoxohexadecahydro-1H-azirino[1,2-a]pyrrolo[1,2-d][1,4,7,10,13]pentaazacyclopentadecin-7-yl)acetate 
• 1352831-42-5 (3S,5R,6S)-3-benzyl-N-(2-(6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)-2-oxo-1,4-diazabicyclo[4.1.0]heptane-5-carboxamide 
• 1352831-52-7 (4R,6aS,11R,11aS)-4-benzyl-N-(2-(6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)-3,6-dioxodecahydro-1H-azirino[1,2-a]pyrrolo[1,2-d][1,4,7]triazonine-11-carboxamide 
• 1352831-51-6 (4S,6aS,11R,11aS)-4-benzyl-N-(2-(6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)-3,6-dioxodecahydro-1H-azirino[1,2-a]pyrrolo[1,2-d][1,4,7]triazonine-11-carboxamide 
• 1352831-50-5 (1S,4S,6aR,11S,11aR)-4-(4-(tert-butoxy)benzyl)-N-(2-(6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)-1-isobutyl-3,6-dioxodecahydro-1H-azirino[1,2-a]pyrrolo[1,2-d][1,4,7]triazonine-11-carboxamide 
• 1352831-57-2 (1S,4S,7S,9aR,14S,14aR)-7-benzyl-N-(2-(6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)-1-isobutyl-4-methyl-3,6,9-trioxotetradecahydroazirino[1,2-a]pyrrolo[1,2-d][1,4,7,10]tetraazacyclododecine-14-carboxamide 

Relevant academic research and scientific papers

Solvatochromic reagents for multicomponent reactions and their utility in the development of cell-permeable macrocyclic peptide vectors

Sensitive scaffolds: An isocyanide equipped with an environment-sensitive fluorophore was used to synthesize peptide macrocycles. The photophysical properties of the product macrocycles are sensitive to both peptide sequence and configuration. A mitochondria-penetrating peptide was constrained within a cyclic peptide framework and showed increased uptake and localization relative to a linear control (see scheme). Copyright

PHYTOSPHINGOSINE DERIVATIVES AS ADJUVANTS IN IMMUNE STIMULATION

The invention relates to phytosphingosine derivatives, suitable as adjuvants in immune stimulation. The invention further relates to pharmaceutical compositions comprising such compounds and the medical use of said compounds and/or compositions in therapeutic or prophylactic methods of immune stimulation in a subject, and for use in the treatment of a disease, for which stimulation of an immune response in a subject produces a therapeutic benefit. The invention further relates to the phytosphingosine derivative as described herein for use as an adjuvant in a method of vaccinating a subject. The invention further relates to the phytosphingosine derivative as described herein for use in stimulating antibody production, stimulating an immune response against infection, stimulating an immune response against a cancer, or preventing and/or treating septic shock. The invention further relates to a method for the manufacture of said derivatives comprising an Ugi-4-component reaction (Ugi-4CR).