1352833-87-4

Upstream product

• 5708-19-0 (1S)-3-cyclohexenecarboxylic acid 
• 67976-82-3 (1S)-3-cyclohexene-1-carboxylic acid (R)-(+)-α-methylbenzylamine salt 
• 4771-80-6 1,2,5,6-tetrahydrobenzoic acid 
• 1350734-49-4 tert-butyl ((1S,3S,6R)-7-oxabicyclo[4.1.0]heptan-3-yl)carbamate 
• 1352834-09-3 cyclohex-3-ene-1-carboxylic acid (R)-(+)-1-phenylethanamine salt 
• 1350734-43-8 {(1S,2S,4S)-4-[(tert-butoxycarbonyl)-amino]-2-hydroxy-cyclohexyl}-benzene-carbothioate 

Downstream Products

• 1061337-55-0 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin 
• 1352833-93-2 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate 

Relevant academic research and scientific papers

Process for the preparation of pleuromutilins

A process for the preparation of a compound of formula in the form of a single stereoisomer, comprising deprotecting the amine group in an N-protected amino-hydroxy-cyclohexylsulfanyl-acetyl-mutilin of formula wherein R is an amine protecting group in the form of a single stereoisomer, and isolating a compound of formula I in the form of a single stereoisomer obtained from the reaction mixture; compounds obtainable by such processes, e.g. a compound of formula I in a crystalline form, or salts of a compound of formula I in crystalline form, and processes for the preparation of intermediates for the production of a compound of formula I.