1352881-82-3

Basic information

• Product Name: 5-bromo-3-iodopyrazolo[1,5-a]pyridine
• Synonyms: 5-bromo-3-iodopyrazolo[1,5-a]pyridine
• CAS NO: 1352881-82-3
• Molecular Formula: C7H4BrIN2
• Molecular Weight: 322.92853
• Mol File: 1352881-82-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 2.41±0.1 g/cm3(Predicted)
• PKA: -0.04±0.30(Predicted)
• CAS DataBase Reference: 5-bromo-3-iodopyrazolo[1,5-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-iodopyrazolo[1,5-a]pyridine(1352881-82-3)
• EPA Substance Registry System: 5-bromo-3-iodopyrazolo[1,5-a]pyridine(1352881-82-3)

Safety Data

• Hazardous Substances Data: 1352881-82-3(Hazardous Substances Data)

Usage

General Description

5-bromo-3-iodopyrazolo[1,5-a]pyridine is a chemical compound with the molecular formula C7H3BrIN2. It is a heterocyclic building block that contains both bromine and iodine atoms, making it useful in organic synthesis and medicinal chemistry. 5-bromo-3-iodopyrazolo[1,5-a]pyridine is commonly utilized in the development of pharmaceutical drugs and agrochemicals due to its potential for creating novel molecular structures with desired biological activities. The presence of both bromine and iodine in 5-bromo-3-iodopyrazolo[1,5-a]pyridine offers unique reactivity that can be harnessed in the creation of diverse chemical products for various industrial applications, making it a valuable tool in chemical research and development.

Upstream product

• 885276-93-7 ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate 
• 1060812-84-1 5-bromopyrazolo[1,5-a]pyridine 

Downstream Products

• 1621718-60-2 2,4-difluoro-N-(5-(3-(3-hydroxyprop-1-yn-1-yl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxypyridin-3-yl)benzenesulfonamide 

Relevant articles and documents

Efficient salt-induced kinase inhibitor and preparation method thereof

The invention discloses an efficient salt-induced kinase inhibitor and a preparation method thereof, and the efficient salt-induced kinase inhibitor is characterized by comprising substances of a chemical formula in the invention. The salt-induced kinase inhibitor with excellent performance has high inhibitory activity for in-vitro experiments and also has high cell inhibitory activity.

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors

Protein kinase C iota (PKC-i) is an atypical kinase implicated in the promotion of different cancer types. A biochemical screen of a fragment library has identified several hits from which an azaindole-based scaffold was chosen for optimization. Driven by a structure-activity relationship and supported by molecular modeling, a weakly bound fragment was systematically grown into a potent and selective inhibitor against PKC-i.

Novel pyrazolo[1,5-a]pyridines as PI3K inhibitors: Variation of the central linker group

As part of our investigation into the pyrazolo[1,5-a]pyridines as novel PI3K inhibitors, we report a range of analogues where the central linker portion of the molecule was varied while retaining the pyrazolo[1,5-a]pyridine and arylsulfonyl or arylcarbonyl groups. Isostere generating software BROOD was used to assist with producing ideas. The isoform selectivity of the compounds varied from pan-PI3K for compound 41 to p110α-selective for compound 58 or p110δ-selective for compound 57. The latter two compounds varied only in their sulphur oxidation state.