1352893-24-3

Basic information

• Product Name: 6-chlorofuro[3,4-c]pyridin-3(1H)-one
• Synonyms: 6-chlorofuro[3,4-c]pyridin-3(1H)-one;6-chloro-1H,3H-furo[3,4-c]pyridin-3-one
• CAS NO: 1352893-24-3
• Molecular Formula: C7H4ClNO2
• Molecular Weight: 169.56516
• Mol File: 1352893-24-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 388.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.524±0.06 g/cm3(Predicted)
• PKA: -1.27±0.20(Predicted)
• CAS DataBase Reference: 6-chlorofuro[3,4-c]pyridin-3(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chlorofuro[3,4-c]pyridin-3(1H)-one(1352893-24-3)
• EPA Substance Registry System: 6-chlorofuro[3,4-c]pyridin-3(1H)-one(1352893-24-3)

Safety Data

• Hazardous Substances Data: 1352893-24-3(Hazardous Substances Data)

Usage

General Description

6-Chlorofuro[3,4-c]pyridin-3(1H)-one is a chemical compound with the molecular formula C5H3ClNO2. It is a heterocyclic compound that contains a furo[3,4-c]pyridine ring structure with a chlorine atom and a ketone functional group. 6-chlorofuro[3,4-c]pyridin-3(1H)-one has potential applications in organic synthesis and pharmaceutical research due to its unique structure and reactivity. It may be used as a building block in the synthesis of other organic molecules or as a potential drug candidate for further exploration. Additionally, its properties and behavior in chemical reactions make it an interesting target for further study in the field of medicinal chemistry and drug discovery.

Upstream product

• 1425335-86-9 6-chloro-4-(hydroxymethyl)-N,N-bis(propan-2-yl)pyridine-3-carboxamide 
• 905273-88-3 6-chloro-4-formyl-N,N-bis(propan-2-yl)pyridine-3-carboxamide 
• 905273-87-2 6-chloro-N,N-bis(propan-2-yl)pyridine-3-carboxamide 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 

Downstream Products

• 1450723-16-6 6-amino-N-[[4-(benzenesulfonyl)phenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 
• 1450723-54-2 6-chloro-2-[(2,4-dimethoxyphenyl)methyl]-1H,2H,3H-pyrrolo[3.4-c]pyridine 
• 1450723-55-3 N,2-bis[(2.4-dimethoxyphenyl)methyl]-1H,2H,3H-pyrrolo[3,4-c]pyridin-6-amine 
• 1453272-30-4 2-chloro-4,5-bis(chloromethyl)pyridine hydrochloride 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors containing 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas were identified using structure-based design techniques. The new compounds displayed improved aqueous solubilities, determined using a high-throughput solubility assessment, relative to previously disclosed urea and amide-containing NAMPT inhibitors. An optimized 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived compound exhibited potent anti-NAMPT activity (18; BC NAMPT IC50 = 11 nM; PC-3 antiproliferative IC50 = 36 nM), satisfactory mouse PK properties, and was efficacious in a PC-3 mouse xenograft model. The crystal structure of another optimized compound (29; NAMPT IC50 = 10 nM; A2780 antiproliferative IC50 = 7 nM) in complex with the NAMPT protein was also determined.