135292-63-6Relevant articles and documents
Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme
Prado, Verónica,Lence, Emilio,Thompson, Paul,Hawkins, Alastair R.,González-Bello, Concepción
, p. 17988 - 18000 (2016)
Shikimate kinase (SK), the fifth enzyme of the aromatic amino acid biosynthesis, is a recognized target for antibiotic drug discovery. The potential of the distinct dynamic apolar gap, which isolates the natural substrate from the solvent environment for