1352933-57-3

Upstream product

• 1352933-56-2 N-(1-(4,4-dimethoxycyclohexyl)but-3-en-1-yl)acrylamide 
• 1352933-55-1 1-(4,4-dimethoxycyclohexyl)but-3-en-1-amine hydrochloride 
• 1352933-54-0 N-(1-(1,4-dioxaspiro[4.5]decan-8-yl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide 
• 1352933-53-9 (E)-N-(1,4-dioxaspiro[4.5]decan-8-ylmethylene)-2-methylpropane-2-sulfinamide 
• 93245-98-8 1,4-dioxaspiro[4.5]decane-8-carbaldehyde 

Relevant academic research and scientific papers

CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2

The present invention comprises compounds of Formula (I). Wherein: R1, R2, R4, J, Q, and A are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).