1352934-60-1

Basic information

• Product Name: 7-(trifluoroMethyl)-1-Methoxyisoquinoline
• Synonyms: 7-(trifluoroMethyl)-1-Methoxyisoquinoline
• CAS NO: 1352934-60-1
• Molecular Formula: C₁₁H₈F₃NO
• Molecular Weight: 227.1825296
• Mol File: 1352934-60-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-(trifluoroMethyl)-1-Methoxyisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(trifluoroMethyl)-1-Methoxyisoquinoline(1352934-60-1)
• EPA Substance Registry System: 7-(trifluoroMethyl)-1-Methoxyisoquinoline(1352934-60-1)

Safety Data

• Hazardous Substances Data: 1352934-60-1(Hazardous Substances Data)

Upstream product

• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 1170704-54-7 1-chloro-7-iodoisoquinoline 
• 215453-51-3 7-bromo-1-chloroisoquinoline 

Downstream Products

• 1352934-64-5 2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetic acid 
• 1352934-63-4 methyl 2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetate 
• 1352934-62-3 benzyl (7-(trifluoromethyl)isoquinolin-1-yl)carbamate 
• 1196147-73-5 7-(trifluoromethyl)isoquinolin-1-amine 
• 1352934-61-2 1-phenoxy-7-(trifluoromethyl)isoquinoline 
• 1196154-02-5 1-chloro-7-(trifluoromethyl)isoquinoline 

Relevant articles and documents

A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists

The inflammatory response associated with the activation of C-C chemokine receptor CCR2 via it's interaction with the monocyte chemoattractant protein-1 (MCP-1, CCL2) has been implicated in many disease states, including rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma and neuropathic pain. Small molecule antagonists of CCR2 have been efficacious in animal models of inflammatory disease, and have been advanced into clinical development. The necessity to attenuate hERG binding appears to be a common theme for many of the CCR2 antagonist scaffolds appearing in the literature, presumably due the basic hydrophobic motif present in all of these molecules. Following the discovery of a novel cyclohexyl azetidinylamide CCR2 antagonist scaffold, replacement of the amide bond with heterocyclic rings was explored as a strategy for reducing hERG binding and improving pharmacokinetic properties.