1352945-74-4Relevant articles and documents
Novel one pot synthesis of substituted quinazolin-4(3H)-ones and pyrazolo[4,3-d]pyrimidin-7(6H)-ones using copper iodide, azides and terminal alkynes
Srishyalam,Devanna,Basaveswara Rao,Mulakayala, Naveen
, p. 2889 - 2892 (2017)
A simple and highly efficient copper iodide catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones have been developed from anthranilamide, terminal alkynes and azides. A wide variety of alkynes were screened to understand the scope of this methodology. This method has been extended for the synthesis of 5-substituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones which are having potential applications in medicinal chemistry.
Exploiting interkingdom interactions for development of small-molecule inhibitors of candida albicans biofilm formation
Reen, F. Jerry,Phelan, John P.,Gallagher, Lorna,Woods, David F.,Shanahan, Rachel M.,Cano, Rafael,Muimhneacháin, Eoin ó,McGlacken, Gerard P.,O'Gara, Fergal
, p. 5894 - 5905 (2016)
A rapid decline in the development of new antimicrobial therapeutics has coincided with the emergence of new and more aggressive multidrug-resistant pathogens. Pathogens are protected from antibiotic activity by their ability to enter an aggregative biofilm state. Therefore, disrupting this process in pathogens is a key strategy for the development of next-generation antimicrobials. Here, we present a suite of compounds, based on the Pseudomonas aeruginosa 2-heptyl-4(1H)-quinolone (HHQ) core quinolone interkingdom signal structure, that exhibit noncytotoxic antibiofilm activity toward the fungal pathogen Candida albicans. In addition to providing new insights into what is a clinically important bacterium-fungus interaction, the capacity to modularize the functionality of the quinolone signals is an important advance in harnessing the therapeutic potential of signaling molecules in general. This provides a platform for the development of potent next-generation small-molecule therapeutics targeting clinically relevant fungal pathogens.
The cascade synthesis of quinazolinones and quinazolines using an α-MnO2 catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant
Zhang, Zhe,Wang, Min,Zhang, Chaofeng,Zhang, Zhixin,Lu, Jianmin,Wang, Feng
supporting information, p. 9205 - 9207 (2015/06/02)
Heterogeneously catalyzed synthesis of quinazolinones or quinazolines is reported in this study. An α-MnO2 catalyst is found to be highly active and selective in the oxidative cyclization of anthranilamides or aminobenzylamines with alcohols using TBHP as an oxidant. This protocol exhibits a broad substrate scope, and is operationally simple without an additive.
