135295-89-5Relevant academic research and scientific papers
Transannular Cyclisation Products of a 7-Ethylidenebicyclodecan-3-one
Anastasis, Panayiotis,Duffin, Ray,Matassa, Victor,Overton, Karl H.
, p. 1221 - 1224 (2007/10/02)
Reaction of the enone 1 with toluene-p-sulphonic acid in solvent toluene at reflux furnished the products of ring closure 7-11.
Partial Kinetic 'Resolution' Resulting from a Deuterium Isotope Effect
Anastasis, Panayiotis,Duffin, Raymond,Gilmore, Christopher,Overton, Karl
, p. 801 - 802 (2007/10/02)
The 'racemate' 1A/1B cyclises on heating to the enol 5 via an 'ene' reaction; at two-thirds completion, the recovered enone 1A/1B has D -62 deg (1B has D -132 deg); kinetic 'resolution' results from a deuterium isotope effect for the cyclization (kH/kD ca. 1.8); the absolute stereochemistry of compound 6a is determined by X-ray analysis.
