1352964-64-7

Upstream product

• 142545-26-4 3(S)-Benzyloxycarbonylamino-4-tert-butyldimethylsilyloxypropanecarboxylic acid methyl ester 
• 192517-47-8 methyl (3S)-3-[[(benzyloxy)carbonyl]amino]-4-hydroxybutanoate 
• 3160-47-2 N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester 

Downstream Products

• 1352964-65-8 (S,E)-benzyl 1-(tert-butyldimethylsilyloxy)-9-hydroxy-6-oxonon-4-en-2-ylcarbamate 
• 1352964-70-5 benzyl (2S,9S,E)-1-(tert-butyldimethylsilyloxy)-9-hydroxy-6-oxotridec-4-en-2-ylcarbamate 
• 1352964-75-0 benzyl (2S,9R,E)-1-(tert-butyldimethylsilyloxy)-9-hydroxy-6-oxotridec-4-en-2-ylcarbamate 
• 1352966-43-8 (2S,6S)-1-benzyl-2-((tert-butyldimethylsilyloxy)methyl)-6-methylpiperidine 

Relevant academic research and scientific papers

Enantioselective access to (-)-indolizidines 167B, 209D, 239AB, 195B and (-)-monomorine from a common chiral synthon

An enantioselective access to (-)-indolizidine alkaloids 167B, 209D, 239AB, 195B and (-)-monomorine from a new chiral synthon is described. The use of (S)-3-(Cbz-amino)-4-(tert-butyldimethylsilyloxy)butanal, obtained from l-aspartic acid, has provided eff

Synthesis of (-)-dihydropinidine, (2S,6R)-isosolenopsin and (+)-monomorine via a chiral synthon from l-aspartic acid

The use of a β-amino aldehyde derived from l-aspartic acid as a chiral synthon to construct 2,6-disubstituted piperidines is described. The synthesis of (-)-dihydropinidine·HCl, (2S,6R)-isosolenopsin·HCl and (+)-monomorine has been achieved from this chiral synthon using a Wittig reaction followed by hydrogenation (reductive cyclization) as the key steps.