1352965-43-5

Basic information

• Product Name: N-(4-chlorophenyl)pyridine-2-sulfonamide
• Synonyms: N-(4-chlorophenyl)pyridine-2-sulfonamide
• CAS NO: 1352965-43-5
• Molecular Weight: 268.724
• Mol File: 1352965-43-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-chlorophenyl)pyridine-2-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)pyridine-2-sulfonamide(1352965-43-5)
• EPA Substance Registry System: N-(4-chlorophenyl)pyridine-2-sulfonamide(1352965-43-5)

Safety Data

• Hazardous Substances Data: 1352965-43-5(Hazardous Substances Data)

Upstream product

• 66715-65-9 pyridine-2-sulfonyl chloride 
• 62-53-3 aniline 
• 103863-00-9 N-Phenylpyridine-2-sulfonamide 
• 106-47-8 4-chloro-aniline 
• 2637-34-5 2-Sulfanylpyridine 

Downstream Products

• 1352965-48-0 methyl N-(4-chlorophenyl)-N-[(2-pyridyl)sulfonyl]glycinate 

Relevant articles and documents

Copper-catalyzed mild nitration of protected anilines

A practical copper-catalyzed direct nitration of protected anilines, by using one equivalent of nitric acid as the nitrating agent, has been developed. This procedure features mild reaction conditions, wide structural scope (with regard to both N-protecting group and arene substitution), and high functional-group tolerance. Dinitration with two equivalents of nitric acid is also feasible. Practical and reliable: A Cu-catalyzed selective nitration of para- and ortho-substituted aniline derivatives by using one equivalent of HNO3 has been developed that produces water as the only stoichiometric byproduct (see scheme; PG=protecting group). This method is compatible with strongly electron-deficient substrates, enabling dinitration (by using 2.0 equiv of HNO3). This method allows for a rapid access to relevant nitrogen-containing heterocyclic architectures.

PdII-catalyzed C-H olefination of N-(2-pyridyl)sulfonyl anilines and arylalkylamines

Flexible friend: The N-(2-pyridyl)sulfonyl group acts as a removable directing group in the PdII-catalyzed aryl C-H ortho alkenylation of N-alkyl aniline, benzylamine, and phenethylamine derivatives with electron-poor alkenes. The products were obtained in high yields (70-90 %) and with complete regiocontrol. The mild reductive N-sulfonyl removal enables the construction of a variety of nitrogen heterocycles. EWG=electron-withdrawing group.