1352995-23-3

Upstream product

• 147782-81-8 (2S,4R)-1-<(tert-Butyldimethylsilyl)oxy>-2,4-dimethylpentanal 
• 147782-80-7 (2S,4R)-5-(tert-butyl(dimethyl)silyloxy)-2,4-dimethyl-1-pentanol 
• 1352995-18-6 (2R,4S,5R,6S,Z)-5-((tert-butyldimethylsilyl)oxy)-8-iodo-2,4,6-trimethyloct-7-en-1-ol 
• 1352995-16-4 (5R,6S,8R)-5-((S,Z)-4-iodobut-3-en-2-yl)-2,2,3,3,6,8,11,11,12,12-decamethyl-4,10-dioxa-3,11-disilatridecane 
• 1352995-14-2 (5R,6S,8R)-5-((S)-4-iodobut-3-yn-2-yl)-2,2,3,3,6,8,11,11,12,12-decamethyl-4,10-dioxa-3,11-disilatridecane 
• 1352995-11-9 (2R,4S,5R,6S)-2,4,6-trimethyloct-7-yne-1,5-diol 
• 1352995-45-9 C₁₇H₃₆O₂Si 
• 1352995-07-3 (3S,4R,5S,7R)-8-((tert-butyldimethylsilyl)oxy)-3,5,7-trimethyl-1-(triisopropylsilyl)oct-1-yn-4-ol 
• 1352995-01-7 (2S,4R)-5-((tert-butyldimethylsilyl)oxy)-N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylpentanamide 
• 1352995-46-0 (5R,6S,8R)-5-((S)-but-3-en-2-yl)-2,2,3,3,6,8,11,11,12,12-decamethyl-4,10-dioxa-3,11-disilatridecane 
• 1234501-01-9 [4S-(4-methoxybenzyloxy)-3R,5S-dimethyl-2-oxonon-6Z-enyl]-phosphonic acid di-methyl ester 
• 1352995-20-0 (2R,4S,5R,6S,Z)-5-((tert-butyldimethylsilyl)oxy)-8-iodo-2,4,6-trimethyloct-7-enal 
• 792921-68-7 (3S,4R,5S,7R)-4-(tert-butyldimethylsilyloxy)-7-((tert-butyldimethylsilyloxy)methyl)-3,5-dimethyloct-1-yne 

Downstream Products

• 1352995-25-5 (3Z,5S,6S,7R,11S,13S,14R,15S,16Z)-14-((tert-butyldimethylsilyl)oxy)-17-iodo-6-((4-methoxybenzyl)oxy)-5,7,11,13,15-pentamethylheptadeca-3,16-dien-8-one 

Relevant academic research and scientific papers

Efficient syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi- dictyostatin, two potent new microtubule-stabilizing agents

The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative activity against a variety of human cancer cell lines. Two highly active analogs of dictyostatin, 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, were prepared by a new streamlined total synthesis route. Three complete carbon fragments were prepared to achieve maximum convergency. These were coupled by a Horner-Wadsworth-Emmons reaction sequence and an esterification. A late stage Nozaki-Hiyama-Kishi reaction was then used to form the 22-membered macrolide. The stereoselectivity of this reaction depended on the configurations of the nearby stereocenter at C6.