1352995-80-2Relevant academic research and scientific papers
Highly Enantioselective Kinetic Resolution of Michael Adducts through N-Heterocyclic Carbene Catalysis: An Efficient Asymmetric Route to Cyclohexenes
Chen, Xiang-Yu,Li, Sun,Liu, Qiang,Kumar, Mukesh,Peuronen, Anssi,Rissanen, Kari,Enders, Dieter
, p. 9735 - 9738 (2018)
A highly efficient strategy for the kinetic resolution of Michael adducts was realized using a chiral N-heterocyclic carbene catalyst. The kinetic resolution provides a new convenient route to single diastereomers of cyclohexenes and Michael adducts in good yields with high enantiomeric excesses (up to 99 % ee with a selectivity factor of up to 458). This “two flies with one swat” concept allows the synthesis of these two synthetically valuable compound classes at the same time by a single transformation.
Squaramide-catalyzed enantioselective Michael addition of malononitrile to chalcones
Yang, Wen,Jia, Yang,Du, Da-Ming
experimental part, p. 332 - 338 (2012/02/04)
A highly enantioselective Michael addition of malononitrile to chalcones catalyzed by a chiral quinine-derived squaramide catalyst has been developed. This organocatalytic reaction at a very low catalyst loading (0.5 mol%) led to chiral γ-cyano carbonyl c
