1353011-95-6

Basic information

• Product Name: Chloroacetamido-PEG4-NHS ester
• Synonyms: Chloroacetamido-PEG4-NHS ester;Chloroacetamido-PEG5-NHS ester;Cl-peg4-nhsester;Cl-NH-PEG4-NHS;2,5-Dioxopyrrolidin-1-yl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate
• CAS NO: 1353011-95-6
• Molecular Formula: C17H27ClN2O9
• Molecular Weight: 438.87
• Mol File: 1353011-95-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• PKA: 13.57±0.46(Predicted)
• CAS DataBase Reference: Chloroacetamido-PEG4-NHS ester(CAS DataBase Reference)
• NIST Chemistry Reference: Chloroacetamido-PEG4-NHS ester(1353011-95-6)
• EPA Substance Registry System: Chloroacetamido-PEG4-NHS ester(1353011-95-6)

Safety Data

• Hazardous Substances Data: 1353011-95-6(Hazardous Substances Data)

Usage

Description

Chloroacetamido-PEG4-NHS ester is a PEG (polyethylene glycol) linker that contains chloroacetamide and NHS (N-hydroxysuccinimide) ester functional groups. The chlorine atom in the chloroacetamide group acts as a good leaving group, enabling substitution reactions to occur. The NHS ester is an active ester that can react with primary amines to form stable amide bonds. The hydrophilic PEG linker enhances the compound's hydrophilic properties in aqueous media, making it a versatile molecule for various applications.

Uses

Used in Bioconjugation:
Chloroacetamido-PEG4-NHS ester is used as a bioconjugation agent for the covalent attachment of biomolecules, such as proteins, peptides, and other amine-containing compounds. The NHS ester reacts with primary amines to form stable amide bonds, allowing for the efficient and specific conjugation of target molecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Chloroacetamido-PEG4-NHS ester is used as a component in the development of drug delivery systems. The hydrophilic PEG linker can improve the solubility and stability of drug molecules, enhancing their bioavailability and reducing potential side effects.
Used in Diagnostic Applications:
Chloroacetamido-PEG4-NHS ester is employed as a labeling agent in diagnostic applications, such as immunoassays and fluorescence-based detection methods. The stable amide bond formation with primary amines allows for the efficient attachment of detection probes or markers to biomolecules, improving the sensitivity and specificity of the diagnostic process.
Used in Material Science:
In the field of material science, Chloroacetamido-PEG4-NHS ester is used as a functionalizing agent for the modification of surfaces and materials. The ability to form stable amide bonds with primary amines enables the covalent attachment of various functional groups, improving the properties of materials for specific applications, such as enhanced biocompatibility or improved mechanical strength.