1353047-06-9Relevant academic research and scientific papers
A simple and efficient metal-free synthesis of tetrasubstituted pyrroles by iodine-catalyzed four-component coupling reaction of aldehydes, amines, dialkyl acetylenedicarboxylates, and nitromethane
Das, Biswanath,Bhunia, Nisith,Lingaiah, Maram
, p. 3471 - 3474 (2011)
The four-component coupling reaction of aldehydes, amines, dialkyl acetylenedicarboxylates, and nitromethane in the presence of molecular iodine as a catalyst furnished the corresponding 1,2,3,4-tetrasubstituted pyrroles under reflux. The products are formed in high yields (65-88%) within 8 hours. The method is simple, efficient, cost-effective, and metal-free. Georg Thieme Verlag Stuttgart.
