135308-76-8

Basic information

• Product Name: D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride
• Synonyms: 4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol Hydrochloride;D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride;Venlafaxine O-Desmethyl N,N-Didesmethyl Impurity;1-[2-Amino-1-(4-hydroxyphenyl) ethyl] cyclohexanol HCl
• CAS NO: 135308-76-8
• Molecular Formula: C₁₄H₂₁NO₂*ClH
• Molecular Weight: 0
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 135308-76-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 104-107°C
• Appearance: /
• Storage Temp.: -20?C Freezer
• Solubility: DMSO (Slightly), Methanol (Sparingly, Sonicated)
• CAS DataBase Reference: D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride(135308-76-8)
• EPA Substance Registry System: D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride(135308-76-8)

Safety Data

• Hazardous Substances Data: 135308-76-8(Hazardous Substances Data)

Usage

Description

D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride is a metabolite of Venlafaxine, an antidepressant medication. It is an off-white to tan solid and is derived from the metabolism of the parent drug, Venlafaxine, in the body.

Uses

1. Used in Pharmaceutical Industry:
D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride is used as an active pharmaceutical ingredient (API) for the development of antidepressant medications. It is utilized in the formulation of drugs that target the treatment of various types of depression and anxiety disorders.
2. Used in Research and Development:
D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride is used as a research compound for studying the pharmacological effects, safety, and efficacy of Venlafaxine and its metabolites. It aids in understanding the drug's mechanism of action, metabolism, and potential side effects.
3. Used in Quality Control and Standardization:
D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride is used as a reference standard for quality control and standardization of Venlafaxine-containing pharmaceutical products. It helps ensure the accuracy, precision, and reliability of analytical methods used in the quantification and identification of Venlafaxine and its metabolites in various matrices.
4. Used in Metabolite Profiling and Drug Interaction Studies:
D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride is used in metabolite profiling and drug interaction studies to investigate the metabolic pathways, pharmacokinetics, and potential drug-drug interactions involving Venlafaxine. This information is crucial for optimizing drug dosages, minimizing adverse effects, and improving patient outcomes.

Upstream product

• 108-94-1 cyclohexanone 

Downstream Products

• 93413-62-8 O-desmethylvenlafaxine 

Relevant articles and documents

PROCESS FOR PREPARATION OF 0-DESMETHYLVENLAFAXINE AND ITS ANALOGUES

The present invention belongs to the field of organic chemistry and refers to a process for the preparation of O-desmethylvenlafaxine (l-[2-Dimethylamino)-l-(4-hydroxyphenyl)ethyl]cyclo- hexanol), its analogues and pharmaceutical acceptable salts thereof. The invention also relates to a catalytic hydrogenation of cyano-group of the substituted acetonitrile.