135311-96-5

Upstream product

• 115689-56-0 (4aR,8aS)-5-Trimethylsilanyloxy-3,4,4a,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid tert-butyl ester 
• 115689-57-1 (4aS,8aR)-6-Bromo-5-oxo-octahydro-quinoline-1-carboxylic acid tert-butyl ester 
• 98218-81-6 trans-octahydro-5-oxo-1(2H)-quinolinecarboxylic acid 1,1-dimethylethyl ester 
• 115689-54-8 octahydro-5-hydroxy-1(2H)-quinolinecarboxylic acid 1,1-dimethylethyl ester 
• 92187-37-6 decahydro-5-quinolinol 
• 1006-51-5 2,3,4,6,7,8-hexahydro-5(1H)-quinolinone 
• 115689-07-1 (+/-)-trans-2-amino-5,5a,7,8,9,9a-hexahydrothiazolo<4,5-f>quinoline-6(4H)-carboxylic acid 1,1-dimethylethyl ester 

Relevant academic research and scientific papers

Dopamine Autoreceptor Agonists as Potential Antipsychotics. 3. 6-Propyl-4,5,5a,6,7,8-hexahydrothiazoloquinolin-2-amine

A series of rigid tricyclic analogues of the dopamine (DA) agonist PD 118440 was synthesized and evaluated for dopaminergic activity and DA autoreceptor selectivity. (R)-(+)-6-Propyl-4,5,5a,6,7,8-hexahydrothiazoloquinolin-2-amine ((+)-6) was identified as the most selective DA autoreceptor agonist from this group of compounds.It inhibited spontaneous locomotor activity (LMA) in rodents, reversed the γ-butyrolactone (GBL) induced accumulation of rat striatal DOPA and inhibited brain DA neuronal firing, all suggestive of direct DA autoreceptor agonist activity.However, (+)-6 is not completely free of postsynaptic DA activity, as evidenced by its stimulation of LMA in rats at high doses and its ability to produce stereotypy.On the other hand, (-)-6 appears to be a weak partial DA agonist with some effects on brain DA synthesis only at high doses.Like other DA autoreceptor agonists and DA antagonists, (+)-6 inhibited Sidman conditioned avoidance in squirrel monkeys, a test predictive of clinical antipsychotic activity.However, unlike classical antipsychotics, (+)-6 did not induce dystonias in haloperidol-sensitized squirrel monkeys, suggesting a minimal propensity toward extrapyramidal side effects (EPS).