135313-13-2Relevant academic research and scientific papers
Synthesis and Structure Elucidation of γ-Aminobutyric Acid Conjugates with Lipidic Acids, Lipidic Amino Acids and Lipidic Peptides
Hussain, Rohanah,Toth, Istvan,Gibbons, William A.
, p. 963 - 966 (2007/10/02)
A series of γ-aminobutyric acid esters of lipidic acids, lipidic peptides and γ-aminobutyric acid amides of lipidic α-amino acids and oligomers were synthesised.The GABA conjugates with ester linkages (6j-r) were prepared by coupling the lipidic acids and peptide conjugates to the carboxyl terminus of GABA.Two types of GABA conjugates linked by amide bonds were synthesised.This class included compounds 5d-f in which the amino group of the lipidic amino acid is condensed with the carboxyl function of GABA and compounds 7a-b with the carboxyl terminus of the α-amino acid coupled to the amino group of GABA.The lipidic amino acid peptide oligomers were varied from 1-3 units, and the alkyl side chains ranged from 5-17 carbon atoms in length in order to impart different lipophilicities to the GABA molecule conjugates. Key Words: Amino acids, fatty / Peptides, lipidic / Lipophilic GABA conjugates / Drug delivery
