135321-95-8Relevant articles and documents
Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways
Bifulco, Giuseppe,Chini, Maria Giovanna,D'Auria, Maria Valeria,De Marino, Simona,Festa, Carmen,Giordano, Assunta,Hofstetter, Robert Klaus,Maione, Francesco,Potenza, Marianna,Saviano, Anella,Sciarretta, Martina,Werz, Oliver
, (2021/07/28)
The multiple inhibition of biological targets involved in pro-inflammatory eicosanoid biosynthesis represents an innovative strategy for treating inflammatory disorders in light of higher efficacy and safety. Herein, following a multidisciplinary protocol
ACYLATED ACTIVE AGENTS AND METHODS OF THEIR USE FOR THE TREATMENT OF AUTOIMMUNE DISORDERS
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Page/Page column 61-62, (2019/12/28)
Disclosed herein are acylated active agents (e.g., acylated catechin polyphenols, acylated carotenoids, acylated mesalamines, acylated sugars, acylated shikimic acids, acylated ellagic acid, acylated ellagic acid analogue, and acylated hydroxybenzoic acids), active agent combinations (e.g., with a second agent that is a fatty acid) and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.
Synthesis and antitumor activity of ATB-429 derivatives containing a nitric oxide-releasing moiety
Wang, Chunlan,Xia, Guimin,Liu, Xiujun,Zhang, Rui,Chai, Yun,Zhang, Jun,Li, Xiaoning,Yang, Yang,Wang, Juxian,Liu, Mingliang
, p. 2355 - 2359 (2016/04/20)
A series of novel ATB-429 (an anti-inflammatory candidate) derivatives containing a nitric oxide (NO)-releasing moiety were designed, synthesized and evaluated for their in vitro activity against six human cancer cell lines. Our results reveal that phenyl
