1353221-39-2

Upstream product

• 111229-09-5 1-(2-hydroxyphenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone 
• 2491-36-3 2-(2-bromoacetyl)hydroxybenzene 
• 118-93-4 o-hydroxyacetophenone 
• 1353432-38-8 1-[2-(3-chlorobenzyloxy)phenyl]-2-(1H-1,2,4-triazol-1-yl)ethanone 

Relevant academic research and scientific papers

Synthesis and antifungal activity of 1-[(2-benzyloxy)phenyl]-2-(azol-1-yl)ethanone derivatives: Exploring the scaffold flexibility

Based on the N-(phenethyl)azole backbone of azole antifungals, we designed 1-[(2-benzyloxy)phenyl]-2-(azol-1-yl)ethanone derivatives 2 and 3, containing benzyloxyphenyl scaffold of croconazole. Also these compounds can be considered as flexible analogs, resulted from C2-C3 disconnection of 3′-chloro-3-imidazolylflavanone 1, recently described as antifungal agent. Thus, in this report, we describe the synthesis of 1-[(2-benzyloxy)phenyl]-2-(azol-1-yl)ethanone derivatives 2 and 3 and their biological evaluation against different pathogenic fungi. By comparing the antifungal activity profile of flexible compounds 2 and 3 with that of rigid analog 1, it can be inferred that lower susceptibilities (higher minimum inhibitory concentrations) were observed with flexible compounds. However, among the synthesized compounds, 1-[2-(2,4-dichlorobenzyloxy)phenyl]-2-(1H-imidazol-1-yl)ethanone hydrochloride (2g) showed comparable or more potent antifungal activity in comparison with fluconazole as a standard drug.