1353244-48-0Relevant academic research and scientific papers
Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: Electrochemical studies on the effects of the quinoidal moiety
Diogo, Emilay B.T.,Dias, Gleiston G.,Rodrigues, Bernardo L.,Guimaraes, Tiago T.,Valenca, Wagner O.,Camara, Celso A.,De Oliveira, Ronaldo N.,Da Silva, Mauro G.,Ferreira, Vitor F.,De Paiva, Yen Galdino,Goulart, Marilia O.F.,Menna-Barreto, Rubem F.S.,De Castro, Solange L.,Da Silva Junior, Eufranio N.
, p. 6337 - 6348 (2013)
In our continued search for novel trypanocidal compounds, twenty-six derivatives of para- and ortho-naphthoquinones coupled to 1,2,3-triazoles were synthesized. These compounds were evaluated against the infective bloodstream form of Trypanosoma cruzi, th
Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: Synthesis of novel α- And nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition
Guimar?es, Tiago T.,Pinto, Maria Do Carmo F.R.,Lanza, Juliane S.,Melo, Maria N.,Do Monte-Neto, Rubens L.,De Melo, Isadora M.M.,Diogo, Emilay B.T.,Ferreira, Vitor F.,Camara, Celso A.,Valen?a, Wagner O.,De Oliveira, Ronaldo N.,Frézard, Frédéric,Da Silva Júnior, Eufranio N.
, p. 523 - 530 (2013/07/27)
Continuing our screening program for novel anti-parasite compounds, we synthesized seven 1,4-naphthoquinones coupled to 1,2,3-triazoles, five nor-β-lapachone-based 1,2,3-triazoles and ten α-lapachone-based 1,2,3-triazoles. These and other naphthoquinonoid
On the search for potential anti-Trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions
Da Silva Jr., Eufranio N.,De Melo, Isadora M.M.,Diogo, Emilay B.T.,Costa, Verenice A.,De Souza Filho, José D.,Valen?a, Wagner O.,Camara, Celso A.,De Oliveira, Ronaldo N.,De Araujo, Alexandre S.,Emery, Flávio S.,Dos Santos, Marcelo R.,De Simone, Carlos A.,Menna-Barreto, Rubem F.S.,De Castro, Solange L.
experimental part, p. 304 - 312 (2012/07/27)
Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1,2,3-triazolic para-naphthoquinones, five nor-β-lapachone-based 1,2,3-triazoles, and several other naphthoquinonoid compounds were synthesized and evaluated against the infective bloodstream
Synthesis of 2-(1H-1,2,3-triazol-1-yl)-1,4-naphthoquinones from 2-azido-1,4-naphthoquinone and terminal alkynes
Do Nascimento, Wilson Silva,Camara, Celso Amorim,De Oliveira, Ronaldo Nascimento
experimental part, p. 3220 - 3224 (2011/11/30)
A series of 2-[(4-substituted 1H-1,2,3-triazol-1-yl)-1,4-naphthoquinones were prepared in moderate-to-good yields (51-90%) by the reaction of 2-azido-1,4-naphthoquinone with terminal alkynes in the presence of a catalytic amounts of copper(I) iodide in acetonitrile. Georg Thieme Verlag Stuttgart · New York.
