1353268-76-4Relevant academic research and scientific papers
Total synthesis of halichondrin C
Yamamoto, Akihiko,Ueda, Atsushi,Bremond, Paul,Tiseni, Paolo S.,Kishi, Yoshito
supporting information; experimental part, p. 893 - 896 (2012/02/15)
The first total synthesis of halichondrin C has been completed, highlighted by development of the synthetic method to construct the C8-C14 polycycle. Cr-mediated coupling reactions are used seven times to form a new C-C bond. The acid stability of halicho
