1353279-10-3

Basic information

• Product Name: C₁₂H₁₂N₄O
• CAS NO: 1353279-10-3
• Molecular Weight: 228.253
• Mol File: 1353279-10-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₂N₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₂N₄O(1353279-10-3)
• EPA Substance Registry System: C₁₂H₁₂N₄O(1353279-10-3)

Safety Data

• Hazardous Substances Data: 1353279-10-3(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 73747-25-8 4-(phenylamino)butyronitrile 
• 1370421-76-3 C₁₂H₁₀N₂O₂ 

Downstream Products

• 1353279-08-9 3-amino-1-[{4-(2,4-dimethylphenyl)piperazin-1-yl}propanoyl]-6-N-phenyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-7-one 

Relevant articles and documents

Synthesis of 1,6-disubstituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-7- one derivatives and evaluation of their anticancer activity

Promising anticancer compounds of the type 1,6-disubstituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-7-ones were identified. The target compounds were readily synthesized in a large scale via a sequence of reactions starting from the commercially available primary amines. Their in vitro anti-proliferative activity has been evaluated on prostate (DU-145), colon (HT-29 and HCT-116) and melanoma (A375P) human cancer cell lines. The relationships between the structure and the anticancer activity, covering all tested cancer cell lines, revealed that the compound 5c with 2,4-dimethylphenyl substituent at R2 was the most potent with the IC50 values in the range as low as 0.16 to 0.40 μM.