135329-22-5

Usage

Uses

Used in Scientific Research:
3-Methoxy-2-methylbenzamide is used as a research chemical for various scientific applications. Its unique structure and properties make it a valuable compound for studying chemical reactions and interactions within the field of organic chemistry.
Used in Pharmaceutical Development:
While there is limited information on its specific uses, 3-methoxy-2-methylbenzamide may be employed as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its potential applications in drug development could be explored further through research and experimentation.
Used in Chemical Synthesis:
3-Methoxy-2-methylbenzamide can be used as a building block in the synthesis of more complex organic molecules. Its presence in various chemical reactions may lead to the creation of new compounds with diverse applications in different industries.
It is important to handle 3-methoxy-2-methylbenzamide with care, as its health effects on humans are not fully known. Characteristics such as boiling point, melting point, and density may vary depending on factors like pressure and temperature.

Upstream product

• 55289-06-0 3-methoxy-2-methylbenzoic acid 
• 24487-91-0 3-methoxy-2-methylbenzoyl chloride 

Relevant academic research and scientific papers

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.

Discovery of 3-methyl-N-(1-oxy-3′,4′,5′,6′- tetrahydro-2′H-[2,4′-bipyridine]-1′-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction

The goal of this study was to identify a structurally distinct D4-selective agonist with superior oral bioavailability to our first-generation clinical candidate 1a (ABT-724) for the potential treatment of erectile dysfunction. Arylpiperazines such as (heteroarylmethyl)piperazine 1a, benzamide 2, and acetamides such as 3a,b exhibit poor oral bioavailability. Structure-activity relationship (SAR) studies with the arylpiperidine template provided potent partial agonists such as 4d and 5k that demonstrated no improvement in oral bioavailability. Further optimization with the (N-oxy-2-pyridinyl)piperidine template led to the discovery of compound 6b (ABT-670), which exhibited excellent oral bioavailability in rat, dog, and monkey (68%, 85%, and 91%, respectively) with comparable efficacy, safety, and tolerability to 1a. The N-oxy-2-pyridinyl moiety not only provided the structural motif required for agonist function but also reduced metabolism rates. The SAR study leading to the discovery of 6b is described herein.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.