1353511-75-7Relevant academic research and scientific papers
An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via imidazo[1,2-a]pyridin-2-yl triflate through a Suzuki cross-coupling reaction-direct arylation sequence
Marhadour, Sophie,Bazin, Marc-Antoine,Marchand, Pascal
experimental part, p. 297 - 300 (2012/01/31)
An efficient method to prepare 2,3-diarylimidazo[1,2-a]pyridines is described. The procedure involves a Suzuki cross-coupling reaction followed by a direct arylation at position 3. Imidazo[1,2-a]pyridin-2-yl triflate was identified as a suitable coupling partner, permitting access to a variety of highly functionalized 2,3-diarylimidazo[1,2-a]pyridines.
Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents
Marhadour, Sophie,Marchand, Pascal,Pagniez, Fabrice,Bazin, Marc-Antoine,Picot, Carine,Lozach, Olivier,Ruchaud, Sandrine,Antoine, Maud,Meijer, Laurent,Rachidi, Najma,Le Pape, Patrice
, p. 543 - 556 (2013/02/23)
A novel series of 2,3-diarylimidazo[1,2-a]pyridines was synthesized and evaluated for their antileishmanial activities. Four derivatives exhibited good activity against the promastigote and intracellular amastigote stages of Leishmania major, coupled with a low cytotoxicity against the HeLa human cell line. The impact of compound lipophilicity on antiparasitic activities was investigated by Log D comparison. Although LmCK1 could be the parasitic target for three compounds (13, 18, 21), the inhibition of another target is under study to explain the antileishmanial effect of the most promising compounds.
