1353554-02-5

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 24313-88-0 3,4,5-Trimethoxyaniline 

Downstream Products

• 1353554-20-7 2-amino-4-(2,4-dichlorophenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-19-4 2-amino-4-(4-hydroxy-3-methoxyphenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-10-5 2-amino-5-oxo-4-styryl-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-11-6 2-amino-4-(2-methoxyphenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-16-1 2-amino-4-[4-(dimethylamino)phenyl]-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-23-0 2-amino-4-(2-hydroxynaphthalen-1-yl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-21-8 2-amino-5-oxo-4-(2,4,5-trimethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-22-9 2-amino-5-oxo-4-(2,3,4-trimethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-12-7 2-amino-4-(4-methoxyphenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-09-2 2-amino-4-(4-hydroxyphenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-06-9 2-amino-5-oxo-4-phenyl-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-18-3 2-amino-4-(4-nitrophenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-17-2 2-amino-4-(3-nitrophenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1353554-13-8 2-amino-4-(2-chlorophenyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis, crystal structure and anti-breast cancer activity of some enaminone derivatives

The present work reports the synthesis of some enaminone derivatives bearing a biologically active 3,4-dimethoxyphenyl (3) or 3,4,5-trimethoxyphenyl moieties (5 and 7), respectively. The trimethoxybenzene moiety has been previously reported to confer cyto

Palladium-Catalyzed Synthesis of Diarylamines and 1- and 2-Oxygenated Carbazoles: Total Syntheses of Natural Alkaloids Clauraila A, Clausenal, Clausine P, and 7-Methoxy- O -methylmukonal

The scope and limitations of the strategy for the conversion of 2-anilinocyclohexenones and N -arylcyclohexane enaminones into the 1- and 2-oxygenated carbazole scaffolds, respectively, were evaluated. The one-pot palladium(0)-catalyzed aromatization/meth

Synthesis, crystal structure and effect of indeno[1,2-b]indole derivatives on prostate cancer in vitro. Potential effect against MMP-9

A highly regiospecific synthesis of a series of indenoindoles is reported, together with X-ray studies and their activity against human prostate cancer cells PC-3 and LNCaP in vitro. The most effective compound 7,7-dimethyl-5-[(3,4-dichlorophenyl)]-(4bRS,9bRS)-dihydroxy-4b,5,6,7,8,9bhexahydro-indeno[1,2-b]indole-9,10-dione 7q reduced the viability in both cell lines in a time and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on clonogenic possibly by inhibition of MMP-9 activity. Molecular docking of 7q and 6k into MMP-9 human active site was also performed to determine the probable binding mode.

Novel quinolines bearing a biologically active trimethoxyphenyl moiety as a new class of antitumor agents

The present paper describes the synthesis of some novel 2-amino-4-substituted aryl-5-oxo-1-(3,4,5-trimethoxy)- 1,4,5,6,7,8- hexahydroquinoline-3-carbonitriles 6a-s starting with 3-(3,4,5- trimethoxyanilino) cyclohex-2-enone 3. All the newly synthesized co