1353554-98-9

Basic information

• Product Name: C₂₀H₁₈F₃N₃
• Synonyms: C₂₀H₁₈F₃N₃
• CAS NO: 1353554-98-9
• Molecular Weight: 357.378
• Mol File: 1353554-98-9.mol

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₈F₃N₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₈F₃N₃(1353554-98-9)
• EPA Substance Registry System: C₂₀H₁₈F₃N₃(1353554-98-9)

Safety Data

• Hazardous Substances Data: 1353554-98-9(Hazardous Substances Data)

Upstream product

• 1353556-15-6 5-(4-(trifluoromethyl)phenyl)-1-naphthaldehyde 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 1353554-97-8 2-(5-(4-(trifluoromethyl)phenyl)naphthalen-1-yl)ethanamine 
• 1353556-19-0 1,3-di-Boc-2-(2-(5-(4-(trifluoromethyl)phenyl)naphthalen-1-yl)ethyl)guanidine 
• 41498-06-0 5-bromo-1-naphthaldehyde 
• 1353556-19-0 C₃₀H₃₄F₃N₃O₄ 
• 1353559-10-0 (E)-1-(2-nitrovinyl)-5-(4-(trifluoromethyl)phenyl)naphthalene 

Relevant articles and documents

Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes

Bacterial cell division occurs in conjunction with the formation of a cytokinetic Z-ring structure comprised of FtsZ subunits. Agents that can disrupt Z-ring formation have the potential, through this unique mechanism, to be effective against several of the newly emerging multi-drug resistant strains of infectious bacteria. 1- and 12-Aryl substituted benzo[c]phenanthridines have been identified as antibacterial agents that could exert their activity by disruption of Z-ring formation. Substituted 4- and 5-amino-1-phenylnaphthalenes represent substructures within the pharmacophore of these benzo[c] phenanthridines. Several 4- and 5-substituted 1-phenylnaphthalenes were synthesized and evaluated for antibacterial activity against Staphylococcus aureus and Enterococcus faecalis. The impact of select compounds on the polymerization dynamics of S. aureus FtsZ was also assessed.

ANTIMICROBIAL AGENTS

The invention provides a compound of formula I:or a salt thereof, wherein R3-R8 and X and Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.