1353572-23-2Relevant academic research and scientific papers
Enantioselective cycloisomerization of 1,5-enynes promoted by cyclometalated NHC-PtII-Monophos catalysts
Jullien, Helene,Brissy, Delphine,Retailleau, Pascal,Marinetti, Angela
, p. 5083 - 5086 (2012/03/08)
The enantioselective cycloisomerizations of 1,5-enynes bearing non-migrating oxygen functions at the propargylic carbon atom have been carried out by using Monophos-PtII and Binepine-PtII complexes as chiral precatalysts. They afforded the corresponding bicyclo[3.1.0]hexan-3-one in up to 63 % enantiomeric excess. The stereochemical outcome of these reactions has been investigated in order to highlight possible matching-mismatching effects between the chiral catalyst and chiral substrates with opposite configurations at the stereogenic carbon. A substantial effect of the stereogenic carbon has been evidenced. Copyright
