1353577-91-9Relevant academic research and scientific papers
HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS
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Paragraph 0176; 0182, (2020/08/22)
Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
Suzuki-Miyaura and Negishi approaches to a series of forensically relevant pyridines and pyrimidines
Blachut, Dariusz,Szawkalo, Joanna,Czarnocki, Zbigniew
experimental part, p. 3496 - 3506 (2011/12/04)
A library of 5-aryl-4-methylpyrimidines, phenyl ring-substituted derivatives of 4-benzylpyrimidines, 2,6-benzylpyridines, and 2,6-dibenzyl-4-methylpyridines were prepared. The synthesis of 5-aryl-4-methylpyrimidines was accomplished by Suzuki-Miyaura cross-coupling reaction between arylboronic acids and 5-bromo-4-methylpyrimidine. The 4-benzylpyrimidines and 2,6-benzylpyridines were synthesized by treatment of 4-bromopyrimidine and 2,6-dibromopyridine derivatives with ring-substituted benzylzinc reagents. Georg Thieme Verlag Stuttgart.
