1353579-15-3

Basic information

• Product Name: C₂₃H₂₇NOS
• CAS NO: 1353579-15-3
• Molecular Weight: 365.539
• Mol File: 1353579-15-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₇NOS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₇NOS(1353579-15-3)
• EPA Substance Registry System: C₂₃H₂₇NOS(1353579-15-3)

Safety Data

• Hazardous Substances Data: 1353579-15-3(Hazardous Substances Data)

Upstream product

• 1353579-03-9 C₁₂H₁₃NOS 
• 18880-00-7 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene 
• 15644-91-4 6-ethoxy-2-methylquinolin-4(1H)-one 

Relevant articles and documents

4-Substituted Thioquinolines and Thiazoloquinolines: Potent, Selective, and Tween-80 invitro Dependent Families of Antitubercular Agents with Moderate invivo Activity

Two new families of closely related selective, non-cytotoxic, and potent antitubercular agents were discovered: thioquinolines and thiazoloquinolines. The compounds were found to possess potent antitubercular properties invitro, an activity that is dependent on experimental conditions of MIC determination (resazurin test and the presence or absence of Tween-80). To clarify the therapeutic potential of these compound families, a medicinal chemistry effort was undertaken to generate a lead-like structure that would enable murine efficacy studies and help elucidate the invivo implications of the invitro observations. Although the final compounds showed only limited levels of systemic exposure in mice, modest levels of efficacy invivo at nontoxic doses were observed. Two new families: In this work we identified two new classes of potent antitubercular agents. Synthesis and analysis of the pharmacological properties of several analogues led to the discovery of potent and selective derivatives invitro, with moderate invivo activity.