1353637-44-1

Basic information

• Product Name: 6-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine
• Synonyms: 6-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine
• CAS NO: 1353637-44-1
• Molecular Formula: C₁₁H₁₂ClN₃O
• Molecular Weight: 237.68548
• Mol File: 1353637-44-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine(1353637-44-1)
• EPA Substance Registry System: 6-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine(1353637-44-1)

Safety Data

• Hazardous Substances Data: 1353637-44-1(Hazardous Substances Data)

Usage

General Description

6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine is a chemical compound with the molecular formula C12H13ClN2O. It is a pyrazolopyridine derivative with a chloro substituent at the 6 position and a tetrahydro-2H-pyran-2-yl group attached to the 1 position. 6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine has potential pharmaceutical applications due to its ability to interact with biological targets such as enzymes or receptors. Its unique structure and properties make it a subject of interest in medicinal chemistry and drug development, with potential for therapeutic use in the treatment of various diseases or disorders. Further research and studies are needed to fully understand its potential pharmacological properties and biological activities.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 1206979-33-0 6-chloro-1H-pyrazolo[4,3-c]pyridine 

Relevant articles and documents

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability

Pim kinases have been identified as promising therapeutic targets for hematologic-oncology indications, including multiple myeloma and certain leukemia. Here, we describe our continued efforts in optimizing a lead series by improving bioavailability while maintaining high inhibitory potency against all three Pim kinase isoforms. The discovery of extensive intestinal metabolism and major metabolites helped refine our design strategy, and we observed that optimizing the pharmacokinetic properties first and potency second was a more successful approach than the reverse. In the resulting work, novel analogs such as 20 (GNE-955) were discovered bearing 5-azaindazole core with noncanonical hydrogen bonding to the hinge.

5-AZAINDAZOLE COMPOUNDS AND METHODS OF USE

5-Azaindazole compounds of Formula (I), including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.