135365-09-2

Basic information

• Product Name: cis-6,10b-dihydro-10b-methyl-5-phenyl-5H-oxazolo<2,3-a>isoquinoline-2,3-dione
• CAS NO: 135365-09-2
• Molecular Weight: 293.322
• Mol File: 135365-09-2.mol

Chemical Properties

• CAS DataBase Reference: cis-6,10b-dihydro-10b-methyl-5-phenyl-5H-oxazolo<2,3-a>isoquinoline-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: cis-6,10b-dihydro-10b-methyl-5-phenyl-5H-oxazolo<2,3-a>isoquinoline-2,3-dione(135365-09-2)
• EPA Substance Registry System: cis-6,10b-dihydro-10b-methyl-5-phenyl-5H-oxazolo<2,3-a>isoquinoline-2,3-dione(135365-09-2)

Safety Data

• Hazardous Substances Data: 135365-09-2(Hazardous Substances Data)

Upstream product

• 25611-78-3 (R,S)-1,2-diphenylethylamine 
• 21511-90-0 N-(1,2-diphenylethyl)acetamide 

Downstream Products

• 135365-21-8 1-methyl-3-phenyl-3,4-dihydroisoquinoline 

Relevant articles and documents

A Modified Bischler-Napieralski Procedure for the Synthesis of 3-Aryl-3,4-dihydroisoquinolines

A modification of the Bischler-Napieralski reaction for the cyclization of (1,2-diphenylethyl)amides to the 3-aryl-3,4-dihydroisoquinolines is presented.Elimination of the amide group as the nitrile via the retro-Ritter reaction is avoided by its conversion to an N-acyliminium intermediate with oxalyl chloride-FeCl3.Removal of the oxalyl group in refluxing MeOH-sulfuric acid provides the 3,4-dihydroisoquinolines in moderate to high yields.The method is also highly effective with (2-phenylethyl)amides.