1353719-50-2Relevant academic research and scientific papers
Highly diastereoselective and enantioselective Michael addition of 5H-oxazol-4-ones to α,β-unsaturated ketones catalyzed by a new bifunctional organocatalyst with broad substrate scope and applicability
Huang, Huicai,Zhu, Kailong,Wu, Wenbin,Jin, Zhichao,Ye, Jinxing
experimental part, p. 461 - 463 (2012/01/06)
A new thiourea-tertiary amine bifunctional catalyst derived from l-tert-leucine was developed and provides excellent stereocontrol in a novel and direct Michael addition of 5H-oxazol-4-ones to α,β-unsaturated ketones with much broad substrate scope. The conjugate addition products with chiral vicinal quaternary and tertiary stereocenters can be easily transformed to structurally interesting compounds or building blocks.
