135380-27-7

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 135380-26-6 (1-benzyl-3-(hydroxymethyl)pyrrolidin-3-yl)methanol 
• 1313369-59-3 3,3-dimethyl 1-benzylpyrrolidine-3,3-dicarboxylate 
• 17012-21-4 1-benzylpyrrolidine-3-carboxylic acid methyl ester 

Downstream Products

• 1352926-14-7 tert-butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate 
• 1523618-25-8 2C₁₁H₂₀N₂O₂*C₂H₂O₄ 

Relevant academic research and scientific papers

1-azaspirocycle compound, and preparation method and applications thereof

The invention discloses a 1-azaspirocycle compound, and preparation method and applications thereof, and belongs to the field of pharmaceutical chemistry. The 1-azaspirocycle compound with a structurerepresented by formula I, or a pharmaceutically acceptable salt or a stereisomer or a solvate or a prodrug thereof is capable of realzing combination with Autotaxin, can be taken as an Autotaxin inhibitor, and can be used for prevention and treatment of diseases with Autotaxin expression increasing pathological characteristics such as cancer and fibrosis diseases especially pulmonary fibrosis andhepatic fibrosis, metabolic diseases, myelodysplastic syndrome, cardiovascular diseases, autoimmune diseases, inflammation, neurological diseasses, or pain. Compared with single component inhibitors,the 1-azaspirocycle compound and the derivatives possesses following advantages: blocking and interfacing at the upsteam of a plurality of key signal channels are realized, tumor cell growth and transfer are relieved or dalyed, early caused drug resistance is avoided, and novel means are provided for treatment of tumor cells.

Synthesis of Orthogonally Protected 2,6-Diazaspiro[35]nonane and 2,6-Diazaspiro[3.4]octane Analogues as Versatile Building Blocks in Medicinal Chemistry

A novel and efficient synthesis of orthogonally protected spirocyclic amines is described for the first time.