135380-27-7

Basic information

• Product Name: 6-benzyl-2-(p-tolylsulfonyl)-2,6-diazaspiro[3.4]octane
• CAS NO: 135380-27-7
• Molecular Formula: C₂₀H₂₄N₂O₂S
• Molecular Weight: 356.48
• Mol File: 135380-27-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 500.2°C at 760 mmHg
• Flash Point: 256.3°C
• Density: 1.29g/cm³
• Vapor Pressure: 3.87E-10mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 6-benzyl-2-(p-tolylsulfonyl)-2,6-diazaspiro[3.4]octane(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyl-2-(p-tolylsulfonyl)-2,6-diazaspiro[3.4]octane(135380-27-7)
• EPA Substance Registry System: 6-benzyl-2-(p-tolylsulfonyl)-2,6-diazaspiro[3.4]octane(135380-27-7)

Safety Data

• Hazardous Substances Data: 135380-27-7(Hazardous Substances Data)

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 135380-26-6 (1-benzyl-3-(hydroxymethyl)pyrrolidin-3-yl)methanol 
• 1313369-59-3 3,3-dimethyl 1-benzylpyrrolidine-3,3-dicarboxylate 
• 17012-21-4 1-benzylpyrrolidine-3-carboxylic acid methyl ester 

Downstream Products

• 1352926-14-7 tert-butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate 
• 1523618-25-8 2C₁₁H₂₀N₂O₂*C₂H₂O₄ 

Relevant articles and documents

1-azaspirocycle compound, and preparation method and applications thereof

The invention discloses a 1-azaspirocycle compound, and preparation method and applications thereof, and belongs to the field of pharmaceutical chemistry. The 1-azaspirocycle compound with a structurerepresented by formula I, or a pharmaceutically acceptable salt or a stereisomer or a solvate or a prodrug thereof is capable of realzing combination with Autotaxin, can be taken as an Autotaxin inhibitor, and can be used for prevention and treatment of diseases with Autotaxin expression increasing pathological characteristics such as cancer and fibrosis diseases especially pulmonary fibrosis andhepatic fibrosis, metabolic diseases, myelodysplastic syndrome, cardiovascular diseases, autoimmune diseases, inflammation, neurological diseasses, or pain. Compared with single component inhibitors,the 1-azaspirocycle compound and the derivatives possesses following advantages: blocking and interfacing at the upsteam of a plurality of key signal channels are realized, tumor cell growth and transfer are relieved or dalyed, early caused drug resistance is avoided, and novel means are provided for treatment of tumor cells.