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Flezelastine is a chemical compound classified under the organic compounds known as indanes. It is recognized for its role as an active pharmaceutical ingredient, particularly in the form of a nasal spray for managing allergic rhinitis. Flezelastine operates by binding to histamine receptors in the nasal mucosa, effectively blocking histamine's effects and alleviating symptoms such as nasal congestion, sneezing, and itching. Its anti-inflammatory and anti-allergic properties contribute to its status as an effective and well-tolerated treatment option for allergic rhinitis. However, like any medication, Flezelastine may have potential side effects and interactions with other drugs, necessitating its use under the supervision of a healthcare professional.

135381-77-0

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135381-77-0 Usage

Uses

Used in Pharmaceutical Industry:
Flezelastine is used as an active ingredient in pharmaceutical products for the treatment of allergic rhinitis. It is particularly effective as a nasal spray, where it serves to bind to histamine receptors in the nasal mucosa, thereby blocking histamine's effects and reducing the symptoms associated with allergic rhinitis.
Used in Allergy Management:
Flezelastine is used as a therapeutic agent for allergy management, specifically targeting the symptoms of allergic rhinitis. Its anti-inflammatory and anti-allergic properties make it a valuable tool in reducing nasal congestion, sneezing, and itching, providing relief to individuals suffering from allergies.

Check Digit Verification of cas no

The CAS Registry Mumber 135381-77-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,3,8 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 135381-77:
(8*1)+(7*3)+(6*5)+(5*3)+(4*8)+(3*1)+(2*7)+(1*7)=130
130 % 10 = 0
So 135381-77-0 is a valid CAS Registry Number.
InChI:InChI=1/C29H30FN3O/c30-24-14-12-23(13-15-24)21-28-26-10-4-5-11-27(26)29(34)33(31-28)25-9-6-18-32(20-17-25)19-16-22-7-2-1-3-8-22/h1-5,7-8,10-15,25H,6,9,16-21H2

135381-77-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[(4-fluorophenyl)methyl]-2-[1-(2-phenylethyl)azepan-4-yl]phthalazin-1-one

1.2 Other means of identification

Product number -
Other names flezelastine[inn]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:135381-77-0 SDS

135381-77-0Upstream product

135381-77-0Downstream Products

135381-77-0Related news

Azelastine and Flezelastine (cas 135381-77-0) as reversing agents of multidrug resistance: Pharmacological and molecular studies08/11/2019

The effects of two new phthalazinone derivatives, azelastine (AZ) and flezelastine (FZ), on the reversal of resistance to doxorubicin (dox) were studied using two variants of the rat C6 glioblastoma cell line, selected with dox (C6 0.5) or with vincristine (C6 1V). Both lines presented a multidr...detailed

Investigation of the stereoselective in vitro metabolism of the chiral antiasthmatic/antiallergic drug Flezelastine (cas 135381-77-0) by high-performance liquid chromatography and capillary zone electrophoresis08/10/2019

An achiral HPLC method using a silica gel column as well as two independent chiral analytical methods by HPLC and capillary zone electrophoresis (CZE) were developed in order to investigate the in vitro metabolism of the racemic antiasthmatic/antiallergic drug flezelastine. The chiral HPLC analy...detailed

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