1353897-46-7Relevant academic research and scientific papers
New method for the synthesis of 4,5-dihydro-1,4-benzothiazepin-3(2H)-ones derivatives
Volovnenko,Tarasiuk,Volovenko, Yu. M.,Tkachuk
experimental part, p. 1043 - 1047 (2012/02/16)
A new method has been developed for the synthesis of 4,5-dihydro-1,4- benzothazepin-3(2H)ones derivatives by the acylation of N-substituted 2-chloro-5-nitrobenzylamines with acetylmercaptoacetyl chloride and α-acetylmercaptopropionyl chloride with subsequent removal of the S-acetyl protecting group and intramolecular nucleophilic substitution. The oxidation of 4,5-dihydro-1,4-benzothiazepin-3(2H)-ones to the corresponding 1,1-dioxides has been investigated.
