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1353979-32-4

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1353979-32-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1353979-32-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,3,9,7 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1353979-32:
(9*1)+(8*3)+(7*5)+(6*3)+(5*9)+(4*7)+(3*9)+(2*3)+(1*2)=194
194 % 10 = 4
So 1353979-32-4 is a valid CAS Registry Number.

1353979-32-4Upstream product

1353979-32-4Downstream Products

1353979-32-4Relevant articles and documents

Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903

Sharma, Swagat H.,Pablo, Juan Lorenzo,Montesinos, Monica Suarez,Greka, Anna,Hopkins, Corey R.

supporting information, p. 155 - 159 (2018/12/11)

The transient receptor potential cation channel 5 (TRPC5) has been previously shown to affect podocyte survival in the kidney. As such, inhibitors of TRPC5 are interesting candidates for the treatment of chronic kidney disease (CKD). Herein, we report the synthesis and biological characterization of a series of N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors. Work reported here evaluates the benzimidazole scaffold and substituents resulting in the discovery of AC1903, a TRPC5 inhibitor that is active in multiple animal models of CKD.

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