13540-66-4

Upstream product

• 591-50-4 iodobenzene 
• 1070-83-3 tert-Butylacetic acid 
• 6921-34-2 benzylmagnesium chloride 
• 6802-75-1 diethyl isopropylidenemalonate 
• 100-44-7 benzyl chloride 
• 5415-86-1 diethyl 2-(2-methyl-1-phenylpropan-2-yl)malonate 
• 13705-45-8 3,3-dimethyl-4-phenylbutanenitrile 

Downstream Products

• 33214-68-5 3,3-dimethyl-4-phenyl-butan-1-ol 
• 105474-54-2 (4-bromo-2,2-dimethyl-butyl)-benzene 
• 28080-86-6 2,2-dimethyl-1-phenylbutane 
• 94800-93-8 ethyl 3,3-dimethyl-4-phenylbutanoate 
• 105971-52-6 β-Benzyl-β-methyl-butyramid 
• 33209-64-2 3,3-dimethyl-4-(4-nitrophenyl)butanoic acid 
• 102472-14-0 3-Benzyl-isovaleriansaeure-allethrolonylester 
• 33209-65-3 3,3-Dimethyl-4-p-aminophenylbuttersaeure 
• 33209-66-4 4-(4-hydroxyphenyl)-3,3-dimethylbutanoate 
• 33214-65-2 3,3-Dimethyl-4-p-anisyl-1-butanol 

Relevant academic research and scientific papers

Ligand-Enabled γ-C(sp3)?H Olefination of Free Carboxylic Acids

We report the ligand-enabled C?H activation/olefination of free carboxylic acids in the γ-position. Through an intramolecular Michael addition, δ-lactones are obtained as products. Two distinct ligand classes are identified that enable the challenging palladium-catalyzed activation of free carboxylic acids in the γ-position. The developed protocol features a wide range of acid substrates and olefin reaction partners and is shown to be applicable on a preparatively useful scale. Insights into the underlying reaction mechanism obtained through kinetic studies are reported.

Ligand-Enabled PdII-Catalyzed Iterative γ-C(sp3)?H Arylation of Free Aliphatic Acid

C?H functionalization of aliphatic carboxylic acids without attaching exogenous auxiliary has been so far limited at the proximal β-position. In this work, we demonstrate a ligand enabled palladium catalyzed first regioselective distal γ-C(sp3)?H function