1354005-01-8Relevant academic research and scientific papers
Catalytic asymmetric bromolactonization reactions using (DHQD) 2PHAL-benzoic acid combinations
Armstrong, Alan,Braddock, D. Christopher,Jones, Alexander X.,Clark, Stacy
, p. 7004 - 7008 (2013)
Catalytic (DHQD)2PHAL as modified by added benzoic acid, is an off-the-shelf catalyst-additive combination for effecting catalytic asymmetric bromolactonization reactions. This combination delivers bromolactones with asymmetric induction at a c
Catalyst-Controlled Regio- and Stereoselective Bromolactonization with Chiral Bifunctional Sulfides
Shirakawa, Seiji,Tsuchihashi, Ayano
supporting information, p. 1662 - 1666 (2019/08/28)
Highly regioselective 5- exo bromolactonizations of stilbene-type carboxylic acids bearing electron-withdrawing substituents are achieved for the first time via the use of chiral bifunctional sulfide catalysts possessing a urea moiety. The chiral phthalide products are obtained in moderate to good enantioselectivities as the result of 5- exo cyclizations.
An enantioselective approach toward 3,4-dihydroisocoumarin through the bromocyclization of styrene-type carboxylic acids
Chen, Jie,Zhou, Ling,Tan, Chong Kiat,Yeung, Ying-Yeung
experimental part, p. 999 - 1009 (2012/03/26)
A facile and enantioselective approach toward 3,4-dihydroisocoumarin was developed. The method involved an amino-thiocarbamate catalyzed enantioselective bromocyclization of styrene-type carboxylic acids, yielding 3-bromo-3,4-dihydroisocoumarins with good yields and ee's. 3-Bromo-3,4- dihydroisocoumarins are versatile building blocks for various dihydroisocoumarin derivatives in which the Br group can readily be modified to achieve biologically important 4-O-type and 4-N-type 3,4-dihydroisocoumarin systems. In addition, studies indicated that, by refining some parameters, the synthetically useful 5-exo phthalide products could be achieved with good yields and ee's.
