Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1354037-26-5

Post Buying Request

1354037-26-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1354037-26-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1354037-26-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,4,0,3 and 7 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1354037-26:
(9*1)+(8*3)+(7*5)+(6*4)+(5*0)+(4*3)+(3*7)+(2*2)+(1*6)=135
135 % 10 = 5
So 1354037-26-5 is a valid CAS Registry Number.

1354037-26-5Downstream Products

1354037-26-5Relevant articles and documents

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing

Fedorov, Oleg,Huber, Kilian,Eisenreich, Andreas,Filippakopoulos, Panagis,King, Oliver,Bullock, Alex N.,Szklarczyk, Damian,Jensen, Lars J.,Fabbro, Doriano,Trappe, Joerg,Rauch, Ursula,Bracher, Franz,Knapp, Stefan

, p. 67 - 76 (2011)

There is a growing recognition of the importance of protein kinases in the control of alternative splicing. To define the underlying regulatory mechanisms, highly selective inhibitors are needed. Here, we report the discovery and characterization of the dichloroindolyl enaminonitrile KH-CB19, a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4). Cocrystal structures of KH-CB19 with CLK1 and CLK3 revealed a non-ATP mimetic binding mode, conformational changes in helix αC and the phosphate binding loop and halogen bonding to the kinase hinge region. KH-CB19 effectively suppressed phosphorylation of SR (serine/arginine) proteins in cells, consistent with its expected mechanism of action. Chemical inhibition of CLK1/CLK4 generated a unique pattern of splicing factor dephosphorylation and had at low nM concentration a profound effect on splicing of the two tissue factor isoforms flTF (full-length TF) and asHTF (alternatively spliced human TF).

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1354037-26-5