1354044-37-3

Upstream product

• 503-20-8 fluoroacetonitrile 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1354041-37-4 5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-pyrimidin-4-amine 
• 1354041-76-1 C₁₇H₁₂F₂N₆O 

Relevant academic research and scientific papers

Method for synthesizing 5-flucytosine

The invention discloses a method for synthesizing 5-flucytosine and belongs to the field of organic chemistry. The method comprises the following reaction steps of: adopting fluoroacetonitrile as a raw material, firstly reacting with N,N-dimethyl formamide dimethylacetal to generate 2-fluoro-3-dimethylaminoacrylonitrile, then reacting with urea to obtain an intermediate, and then under the existence of alkali, carrying out cyclization reaction to generate the 5-flucytosine. The method disclosed by the invention has the beneficial effects that the whole process only needs three step reactions,the reaction steps are short, the operation is easy, the use of dangerous chemicals such as fluorine gas and the like is avoided, the total yield reaches not less than 50%, so that the method is suitable for industrial large-scale production.