1354047-18-9

Upstream product

• 888941-69-3 C₁₇H₁₁Cl₂N₃ 

Downstream Products

• 1354047-24-7 7-(3,4-dichlorophenyl)-2-(ethylthio)-5-phenyl-3H-pyrrolo[2,3-d]pyrimidine-4(7H)-one 
• 1354047-27-0 7-(3,4-dichlorophenyl)-2-hydrazinyl-5-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one 
• 1354047-35-0 8-(3,4-dichlorophenyl)-3-methyl-6-phenyl-1H-pyrrolo[2,3-d]-[1,2,4]triazolo[4,3-a]pyrimidin-5(8H)-one 
• 1354047-21-4 7-(3,4-dichlorophenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one 

Relevant academic research and scientific papers

Synthesis and Kinetic Testing of Tetrahydropyrimidine-2-thione and Pyrrole Derivatives as Inhibitors of the Metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

Metallo-β-lactamases (MBLs), produced by an increasing number of bacterial pathogens, facilitate the hydrolysis of many commonly used β-lactam antibiotics. There are no clinically useful antagonists against MBLs. Two sets of tetrahydropyrimidine-2-thione and pyrrole derivatives were synthesized and assayed for their inhibitory effects on the catalytic activity of the IMP-1 MBL from Pseudomonas aeruginosa and Klebsiella pneumoniae. Nine compounds tested (1a, 3b, 5c, 6b, 7a, 8a, 11c, 13a, and 16a) showed micromolar inhibition constants (Ki values range from ~20-80μm). Compounds 1c, 2b, and 15a showed only weak inhibition. In silico docking was employed to investigate the binding mode of each enantiomer of the strongest inhibitor, 5c (Ki=19±9μm), as well as 7a (Ki=21±10μm), the strongest inhibitor of the pyrrole series, in the active site of IMP-1.

Synthesis of new pyrroles of potential anti-inflammatory activity

We herein disclose a series of novel pyrrole derivatives 1-4 and pyrrolo[2,3-d]pyrimidine derivatives 6-11 as novel potent anti-inflammatory compounds. The structures were confirmed by IR, 1H-NMR, and MS. Some newly synthesized compounds were e