13541-03-2

Upstream product

• 5406-33-7 4-chlorobenzyl acetate 
• 64-04-0 phenethylamine 
• 13540-95-9 N-(4-chlorobenzylidene)-2-phenylethanamine 
• 104-88-1 4-chlorobenzaldehyde 
• 39887-24-6 N-(2-phenylethyl)-p-chlorobenzamide 

Downstream Products

• 39887-24-6 N-(2-phenylethyl)-p-chlorobenzamide 

Relevant academic research and scientific papers

Metal-Free Thermal Activation of Molecular Oxygen Enabled Direct α-CH2-Oxygenation of Free Amines

Direct oxidation of α-CH2 group of free amines is hard to achieve due to the higher reactivity of amine moiety. Therefore, oxidation of amines involves the use of sophisticated metallic reagents/catalyst in the presence or absence of hazardous oxidants under sensitive reaction conditions. A novel method for direct C-H oxygenation of aliphatic amines through a metal-free activation of molecular oxygen has been developed. Both activated and unactivated free amines were oxygenated efficiently to provide a wide variety of amides (primary, secondary) and lactams under operationally simple conditions without the aid of metallic reagents and toxic oxidants. The method has been applied to the synthesis of highly functionalized amide-containing medicinal drugs, such as O-Me-alibendol and -buclosamide.

Synthesis, spectral, structural, Hirshfeld surface and DFT studies on bis(N-(4-fluorobenzyl)-N-(2-phenylethyl)dithiocarbamato-S,S′)zinc(II) and its use for the preparation of ZnS and ZnO nanoparticles

Two new complexes, bis(N-(2-phenylethyl)-N-(4-fluorobenzyl)dithiocarbamato-S,S′)zinc(II) (1) and bis(N-(2-phenylethyl)-N-(4-chlorobenzyl)dithiocarbamato-S,S′)zinc(II) (2), have been synthesized and characterized by various physicochemical techniques. Structure of 1 has been determined by single crystal X-ray diffraction. Complex 1 is a dimer. Zinc atom is four coordinated with a distorted tetrahedral environment. Geometry optimization, geometrical parameters, molecular electrostatic potential (MEPs) and frontier molecular orbital analysis of dimeric and monomeric structures of 1 have been carried out by DFT methods and compared with the experimental X-ray diffraction data. The noncovalent interactions in the complex 1 have been analyzed using Hirshfeld surface analysis. 1 and 2 have been used as single source precursors for the preparation of zinc sulfide and zinc oxide nanoparticles. As-prepared zinc sulfides and zinc oxides have been characterized by powder X-ray diffraction (PXRD), scanning electron microscope (SEM), UV–vis absorption, photoluminence and energy dispersive X-ray spectroscopy (EDS). X-ray diffraction study reveals that zinc sulfides and zinc oxides are composed of rhombohedral and hexagonal phases, respectively. Photocatalytic activities of zinc sulfides and zinc oxides were evaluated by degradation of rhodamine B in aqueous solution under UV light irradiation. The results demonstrated the capability of zinc sulfides and zinc oxides as photocatalyst under UV irradiation to degrade the dye.

Synthesis, spectral, structural and computational studies on NiS4 and NiS2NP chromophores: Anagostic and C-H?π (chelate) interactions in [Ni(dtc)(PPh3)(NCS)] (dtc = N-(2-phenylethyl)-N-(4-methoxybenzyl)- dithiocarbamate an

Bis(N-(2-phenylethyl)-N-substituted benzyldithiocarbamato-S,S′)nickel(II) (1-6) and (N-(2-phenylethyl)-N-substituted benzyldithiocarbamato-S,S′)(thiocyanato-N) (triphenylphosphine)nickel(II) (7-12) [substituted benzyl = 2HO-C6H4-CHs

Tandem synthesis of amides and secondary amines from esters with primary amines under solvent-free conditions

An iridium(III)-catalyzed tandem synthesis of amides and amines from esters under solvent-free conditions is described. A commercially available iridium(III) complex, [Cp*IrCl2]2, with sodium acetate showed the best activity for the synthesis of amides and secondary amines. The amide was formed by ester-amide exchange which generates an alcohol in situ which is subsequently transformed to a secondary amine via hydrogen autotransfer. This synthetic protocol with high atom economy generates water as the sole by-product and can afford amides and amines from various esters in a one-pot reaction, expanding the synthetic versatility of ester transformations.